Gabriel Bronk

normal_arrow07_60

right-arrow07_60

Gabriel Bronk

QB Experience
“Every month at QB lunches, a Brandeis professor gives an informal talk on something puzzling that has emerged out of his/her research. I always look forward to these talks: they are consistently fascinating, and the extensive discussion among the students and professors provides us with a thorough understanding of the topic. Additionally, I am very happy to be funded by a grant from the QB program, which includes travel expenses to attend conferences.”
Started QB in Fall 2013
MRSEC Research in the Kondev Lab
“Recent discoveries in multiple organisms have found that distant chromosomal loci become attached together by protein-chromatin interactions. Emerging evidence suggests that in some cases such attachments play a functional role – i.e. regulation of gene expression or recombination. I am writing computer simulations of a chromosome to determine whether a particular intrachromosomal attachment exists in yeast and whether this attachment has a functional role. Specifically, we are testing whether two distant loci (MAT and RE) on yeast chromosome III become bound together during the process of mating type switching and unbound when not undergoing mating type switching. Most notably, our preliminary comparison of our simulations to data from mating-type switching experiments provides quantitative evidence for a functional role of the intrachromosomal attachment – i.e. this attachment serves to increase the likelihood of recombination between the loci HML and MAT, which causes the cell to become mating type alpha: the yeast can turn on the attachment in order to increase its likelihood of successfully switching to mating type alpha.”