Gabe is a Ph.D. student in Physics studying theoretical aspects of DNA damage and repair. He is a member of the Kondev Group.
MRSEC Research in the Kondev Lab
“Recent discoveries in multiple organisms have found that distant chromosomal loci become attached together by protein-chromatin interactions. Emerging evidence suggests that in some cases such attachments play a functional role – i.e. regulation of gene expression or recombination. I am writing computer simulations of a chromosome to determine whether a particular intrachromosomal attachment exists in yeast and whether this attachment has a functional role. Specifically, we are testing whether two distant loci (MAT and RE) on yeast chromosome III become bound together during the process of mating type switching and unbound when not undergoing mating type switching. Most notably, our preliminary comparison of our simulations to data from mating-type switching experiments provides quantitative evidence for a functional role of the intrachromosomal attachment – i.e. this attachment serves to increase the likelihood of recombination between the loci HML and MAT, which causes the cell to become mating type alpha: the yeast can turn on the attachment in order to increase its likelihood of successfully switching to mating type alpha.”