Matt is a Ph.D. student in Physics using single-molecule techniques to probe the role of various proteins in DNA transcription. He is a member of both the Kondev and Gelles Labs.
MRSEC Research in the Gelles and Kondev Labs
“Biology is complicated. The inner workings of a single cell is a crowded, messy Rube Goldberg machine with proteins, enzymes, DNA, energy and ions. Somehow, life manages to extract order, function and purposes from a thermodynamics-driven mess of statistical mechanics. To study this mess, we reduce a simple process of biology, the transcription of DNA into mRNA, into the fewest necessary components; DNA, RNA polymerase (the enzyme), and NTPs (the energy). I study how proteins affect the transcription of DNA by observing single molecules at a time. My research focuses on reducing complicated biology to the simplest components.”